Description

The SARS-CoV-2 spike protein, which binds the virus to host cells, is a key target of vaccine development to combat COVID-19, and mutations in this protein have potential to change infectivity and response to disease treatments as well as vaccine efficacy. As of January 2021 more than a dozen mutations in this protein have been detected via sequencing worldwide, and one particular mutation, N501, has been designated a 'Variant of Concern', as epidemiological markers suggest viruses carrying this mutation are significantly more transmissible.

This track presents amino acid mutations identified in the SARS-CoV2 Spike protein, based on the CoVariants: SARS-CoV-2 Mutations and Variants of Interest community annotation at CoVariants.org, supplemented by the Variants of SARS-CoV-2 Wikipedia page.

Mutations in this track: H69-, D80Y, S98F, A222V, N439K, Y453F, S477N, E484, N501, D614G, A626S, P681H, A701B, V1122

Information provided for each mutation, if available, includes:

Display Conventions

The track items are colored based on the date when the mutation was first identified:
RedMost recent (Fall/Winter 2020-2021)
PurpleSummer 2020
BlueOldest (Winter/Spring 2020)

The mutation name, e.g. N501 as well as alternative identifiers (e.g. N501Y, 501Y) can be typed in to the browser position box to navigate the browser to the mutation position and highlight the mutation in the browser window.

Credits

Thanks to Emma B. Hodcroft, Institute of Social and Preventive Medicine, University of Bern, Switzerland for leading and maintaining the community annotation resource on which this track is largely based.

References

CoVariants: SARS-CoV-2 Mutations and Variants of Interest Emma B. Hodcroft, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

Variants of SARS-CoV-2, Wikipedia