ABI1 AML ABL1 CML, ALL, T-ALL ABL2 AML ACSL3 prostate AF15Q14 AML AF1Q ALL AF3p21 ALL AF5q31 ALL AKAP9 papillary thyroid AKT1 breast, colorectal, ovarian, NSCLC AKT2 ovarian, pancreatic ALDH2 leiomyoma ALK ALCL, NSCLC, neuroblastoma, inflammatory myofibroblastic tumour, Spitzoid tumour ALO17 ALCL AMER1 Wilms tumour APC colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS ARHGEF12 AML ARHH NHL ARID1A clear cell ovarian carcinoma, RCC ARID2 hepatocellular carcinoma ARNT AML ASPSCR1 alveolar soft part sarcoma ASXL1 MDS, CMML ATF1 malignant melanoma of soft parts, angiomatoid fibrous histiocytoma ATIC ALCL ATM T-PLL ATP1A1 adrenal aldosterone producing adenoma ATP2B3 adrenal aldosterone producing adenoma ATRX Pancreatic neuroendocrine tumours, paediatric GBM AXIN1 colorectal, endometrial, prostate and hepatocellular carcinomas, hepatoblastoma, sporadic medulloblastoma BAP1 uveal melanoma, breast, NSCLC, RCC BCL10 MALT BCL11A B-CLL BCL11B T-ALL BCL2 NHL, CLL BCL3 CLL BCL5 CLL BCL6 NHL, CLL BCL7A BNHL BCL9 B-ALL BCOR retinoblastoma, AML, APL (translocation) BCR CML, ALL, AML BHD BIRC3 CLL, MALT, MCL, MM BLM BMPR1A BRAF melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour BRCA1 ovarian BRCA2 breast, ovarian, pancreatic BRD3 lethal midline carcinoma of young people BRD4 lethal midline carcinoma of young people BRIP1 BTG1 BCLL BUB1B C12orf9 lipoma C15orf21 prostate C15orf55 lethal midline carcinoma C16orf75 PMBL, Hodgkin lymphoma C2orf44 NSCLC CACNA1D adrenal aldosterone producing adenoma CALR MPN, MDS CAMTA1 epithelioid haemangioendothelioma CANT1 prostate CARD11 DLBCL CARS ALCL CASP8 hepatocellular, oral squamous cell, breast CBFA2T1 AML CBFA2T3 AML CBFB AML CBL AML, JMML, MDS CBLB AML CBLC AML CCDC6 NSCLC CCNB1IP1 leiomyoma CCND1 CLL, B-ALL, breast CCND2 NHL,CLL CCND3 MM CCNE1 serous ovarian CD273 PMBL, Hodgkin lymphoma CD274 PMBL, Hodgkin lymphoma CD74 NSCLC CD79A DLBCL, WM CD79B DLBCL, WM CDC73 parathyroid adenoma CDH1 lobular breast, gastric CDH11 aneurysmal bone cyst CDK12 serous ovarian CDK4 CDK6 ALL CDKN2A melanoma, multiple other tumour types CDKN2C glioma, MM CDKN2a(p14) melanoma, multiple other tumour types CDX2 AML CEBPA AML, MDS CEP1 MPN, NHL CEP89 Spitzoid tumour CHCHD7 salivary gland adenoma CHEK2 CHIC2 AML CHN1 extraskeletal myxoid chondrosarcoma CIC oligodendroglioma, soft tissue sarcoma CIITA PMBL, Hodgkin lymphoma CLIP1 Spitzoid tumour CLTC ALCL, renal CLTCL1 ALCL CMKOR1 lipoma CNOT3 T-ALL COL1A1 dermatofibrosarcoma protuberans, aneurysmal bone cyst COL2A1 COPEB prostate, glioma COX6C uterine leiomyoma CREB1 clear cell sarcoma, angiomatoid fibrous histiocytoma CREB3L1 myxofibrosarcoma CREB3L2 fibromyxoid sarcoma CREBBP ALL, AML, DLBCL, B-NHL CRLF2 B-ALL, Downs associated ALL CRTC3 salivary gland mucoepidermoid CSF3R aCML, CNL, leukaemia lymphoma and MDS associated with severe congenital neutropenia, CMML, de novo AML, MDS CTNNB1 colorectal, ovarian, hepatoblastoma, pleomorphic salivary gland adenoma, other tumour types CUX1 endometrial, melanoma, colorectal, AML, MDS, other tumour types CYLD cylindroma D10S170 papillary thyroid, CML DAXX pancreatic neuroendocrine tumour, paediatric glioblastoma DCTN1 inflammatory myofibroblastic tumour, Spitzoid tumour DDB2 DDIT3 liposarcoma DDX10 AML* DDX5 prostate DDX6 B-NHL DEK AML DICER1 sex cord-stromal tumour, TGCT, embryonal rhabdomyosarcoma, pleuropulmonary blastoma, pituitary blastoma, Wilms tumour, thyroid cancer, other tumour types DNM2 ETP ALL DNMT3A AML DUX4 soft tissue sarcoma EBF1 lipoma ECT2L ETP ALL EGFR glioma, NSCLC EIF3E colorectal EIF4A2 NHL ELF4 AML ELK4 prostate ELKS papillary thyroid ELL AL ELN B-ALL EML4 NSCLC EP300 colorectal, breast, pancreatic, AML, ALL, DLBCL EPS15 ALL ERBB2 breast, ovarian, other tumour types, NSCLC, gastric ERC1 Spitzoid tumour ERCC2 ERCC3 ERCC4 ERCC5 ERG Ewing sarcoma, prostate, AML ETV1 Ewing sarcoma, prostate ETV4 Ewing sarcoma, prostate carcinoma ETV5 prostate ETV6 congenital fibrosarcoma, multiple leukaemia and lymphoma, secretory breast, MDS, ALL EVI1 AML, CML EWSR1 Ewing sarcoma, desmoplastic small round cell tumour , ALL, clear cell sarcoma, sarcoma, myoepithelioma EXT1 EXT2 EZH2 DLBCL EZR NSCLC FACL6 AML, AEL FAM46C MM FANCA FANCC FANCD2 FANCE FANCF FANCG FAS TGCT, nasal NK/T lymphoma, skin squamous cell carcinoma-burn scar related FBXO11 DLBCL FBXW7 colorectal, endometrial, T-ALL FCGR2B ALL FEV Ewing sarcoma FGFR1 MPN, NHL FGFR1OP MPN, NHL FGFR2 gastric, NSCLC, endometrial FGFR3 bladder, MM, T-cell lymphoma FH FHIT pleomorphic salivary gland adenoma FIP1L1 idiopathic hypereosinophilic syndrome FLI1 Ewing sarcoma FLJ27352 PMBL, Hodgkin lymphoma FLT3 AML, ALL FNBP1 AML FOXA1 breast, prostate FOXL2 granulosa-cell tumour of the ovary FOXO1A alveolar rhabdomyosarcoma FOXO3A AL FOXO4 soft tissue sarcoma FOXP1 ALL FSTL3 B-CLL FUBP1 oligodendroglioma FUS liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma FVT1 B-NHL GAS7 AML* GATA1 megakaryoblastic leukaemia of Downs syndrome GATA2 AML (CML blast transformation) GATA3 breast GMPS AML GNA11 uveal melanoma GNAQ uveal melanoma GNAS pituitary adenoma GOLGA5 papillary thyroid, Spitzoid tumour GOPC glioblastoma GPC3 GPHN AL GRAF AML, MDS H3F3A glioma H3F3B chondroblastoma HCMOGT-1 JMML HEAB AML HERPUD1 prostate HEY1 mesenchymal chondrosarcoma HIP1 CMML, NSCLC HIST1H3B glioma HIST1H4I NHL HLA-A Spitzoid tumour HLF ALL HLXB9 AML HMGA1 microfollicular thyroid adenoma, various benign mesenchymal tumours HMGA2 lipoma, leiomyoma, pleomorphic salivary gland adenoma HNRNPA2B1 prostate HOOK3 papillary thyroid HOXA11 CML HOXA13 AML HOXA9 AML* HOXC11 AML HOXC13 AML HOXD11 AML HOXD13 AML* HRAS infrequent sarcomas, rare other tumour types HSPCA NHL HSPCB NHL IDH1 glioblastoma IDH2 glioblastoma IGH@ MM, Burkitt lymphoma, NHL, CLL, B-ALL, MALT, MLCLS IGK@ Burkitt lymphoma, B-NHL IGL@ Burkitt lymphoma IKZF1 ALL, DLBCL IL2 intestinal T-cell lymphoma IL21R NHL IL6ST hepatocellular carcinoma IL7R ALL, ETP ALL IRF4 MM IRTA1 B-NHL ITK peripheral T-cell lymphoma JAK1 ALL JAK2 ALL, AML, MPN, CML JAK3 acute megakaryocytic leukaemia, ETP ALL JAZF1 endometrial stromal tumour JUN sarcoma KCNJ5 adrenal adenoma KDM5A AML KDM5C clear cell renal carcinoma KDM6A renal, oesophageal SCC, MM KDR NSCLC, angiosarcoma KIAA1549 pilocytic astrocytoma KIAA1598 Spitzoid tumour KIF5B NSCLC, Spitzoid tumour KIT GIST, AML, TGCT, mastocytosis, mucosal melanoma KLF4 meningioma KLK2 prostate KMT2D medulloblastoma, renal KRAS pancreatic, colorectal, lung, thyroid, AML, other tumour types KTN1 papillary thyroid LAF4 ALL, T-ALL LASP1 AML LCK T-ALL LCP1 NHL LCX AML LHFP lipoma LIFR salivary adenoma LMNA Spitzoid tumour LMO1 T-ALL, neuroblastoma LMO2 T-ALL LPP lipoma, leukaemia LRIG3 NSCLC LSM14A Spitzoid tumour LYL1 T-ALL MAF MM MAFB MM MALAT1 renal cell carcinoma (childhood epithelioid), lung MALT1 MALT MAML2 salivary gland mucoepidermoid MAP2K1 NSCLC, melanoma, colorectal MAP2K2 NSCLC, melanoma MAP2K4 pancreatic, breast, colorectal MAX pheochromocytoma, endometrioid carcinoma, colon carcinoma MDM2 sarcoma, glioma, colorectal, other tumour types MDM4 glioblastoma, bladder, retinoblastoma MDS1 MDS, AML MDS2 MDS MECT1 salivary gland mucoepidermoid MED12 uterine leiomyoma MEN1 parathyroid tumours, pancreatic neuroendocrine tumour MET papillary renal, head-neck squamous cell MITF melanoma MKL1 acute megakaryocytic leukaemia MLF1 AML MLH1 colorectal, endometrial, ovarian, CNS MLL AML, ALL MLL3 medulloblastoma MLLT1 AL MLLT10 AL MLLT2 AL MLLT3 ALL MLLT4 AL MLLT6 AL MLLT7 AL MN1 AML, meningioma MPL MPN MSF AML* MSH2 colorectal, endometrial, ovarian MSH6 colorectal MSI2 CML MSN ALCL MTCP1 T cell prolymphocytic leukaemia MUC1 B-NHL MUTYH MYB adenoid cystic carcinoma MYC Burkitt lymphoma, amplified in other cancers, B-CLL MYCL1 small cell lung carcinoma MYCN neuroblastoma MYD88 ABC-DLBCL MYH11 AML MYH9 ALCL MYO5A Spitzoid tumour MYST4 AML NAB2 solitary fibrous tumour NACA NHL NBS1 NCOA1 alveolar rhabdomyosarcoma NCOA2 AML, chondrosarcoma NCOA4 papillary thyroid NDRG1 prostate NF1 neurofibroma, glioma NF2 meningioma, acoustic neuroma, renal NFATC2 Ewing sarcoma NFE2L2 NSCLC, HNSCC NFIB adenoid cystic carcinoma, lipoma NFKB2 B-NHL NIN MPN NKX2-1 NSCLC NONO papillary renal NOTCH1 T-ALL NOTCH2 marginal zone lymphoma, DLBCL NPM1 NHL, APL, AML NR4A3 extraskeletal myxoid chondrosarcoma NRAS melanoma, MM, AML, thyroid NRG1 NSCLC NSD1 AML NT5C2 relapse ALL NTRK1 papillary thyroid, Spitzoid tumour NTRK3 congenital fibrosarcoma, secretory breast NUMA1 APL NUP214 AML, T-ALL NUP98 AML NUTM2A endometrial stromal sarcoma NUTM2B endometrial stromal sarcoma OLIG2 T-ALL OMD aneurysmal bone cyst P2RY8 B-ALL, Down syndrome associated ALL PAFAH1B2 MLCLS PALB2 PAX3 alveolar rhabdomyosarcoma PAX5 NHL, ALL, B-ALL PAX7 alveolar rhabdomyosarcoma PAX8 follicular thyroid PBRM1 clear cell renal carcinoma, breast PBX1 pre B-ALL, myoepithelioma PCM1 papillary thyroid, CML, MPN PCSK7 MLCLS PDE4DIP MPN PDGFB DFSP PDGFRA GIST, idiopathic hypereosinophilic syndrome, paediatric glioblastoma PDGFRB MPN, AML, CMML, CML PER1 AML, CMML PHF6 ETP ALL PHOX2B neuroblastoma PICALM TALL, AML, PIK3CA colorectal, gastric, glioblastoma, breast PIK3R1 glioblastoma, ovarian, colorectal PIM1 NHL PLAG1 salivary adenoma PLCG1 angiosarcoma PML APL, ALL PMS1 PMS2 PMX1 AML PNUTL1 AML POT1 CLL POU2AF1 NHL POU5F1 sarcoma PPARG follicular thyroid PPFIBP1 Spitzoid tumour PPP2R1A clear cell ovarian carcinoma PRCC papillary renal PRDM1 DLBCL PRDM16 MDS, AML PRF1 PRKAR1A papillary thyroid PSIP1 AML PTCH1 skin basal cell, medulloblastoma PTEN glioma, prostate, endometrial PTPN11 JMML, AML, MDS PTPRB angiosarcoma PTPRC T-ALL PTPRK colorectal PWWP2A Spitzoid tumour RAB5EP CMML RAC1 melanoma, carcinoma RAD21 AML, endometrium, colorectal, lung RAD51L1 lipoma, uterine leiomyoma RAF1 pilocytic astrocytoma RALGDS PMBL, Hodgkin lymphoma, RANBP17 ALL RAP1GDS1 T-ALL RARA APL RB1 retinoblastoma, sarcoma, breast, small cell lung carcinoma RBM15 acute megakaryocytic leukaemia RECQL4 REL Hodgkin lymphoma RET medullary thyroid, papillary thyroid, pheochromocytoma, NSCLC, Spitzoid tumour RNF43 cholangiocarcinoma, ovary, pancreas ROS1 glioblastoma, NSCLC, Spitzoid tumour RPL10 T-ALL RPL22 AML, CML RPL5 T-ALL RPN1 AML RSPO2 colorectal RSPO3 colorectal RUNDC2A PMBL, Hodgkin lymphoma RUNX1 AML, preB- ALL, T-ALL RUNXBP2 AML SBDS SDC4 NSCLC SDH5 SDHB SDHC SDHD SEPT6 AML SET AML SETBP1 atypical CML, sAML, MDS/MPN-U, CMML, JMML SETD2 clear cell renal carcinoma SF3B1 myelodysplastic syndrome SFPQ papillary renal SFRS3 follicular lymphoma SH2B3 MPN, sAML, erythrocytosis, B-ALL SH3GL1 AL SIL T-ALL SLC34A2 NSCLC SLC45A3 prostate SMAD4 colorectal, pancreatic, small intestine SMARCA4 NSCLC, SCCOHT SMARCB1 malignant rhabdoid SMARCE1 SMO skin basal cell SOCS1 Hodgkin lymphoma, PMBL SOX2 NSCLC, oesophageal squamous carcinoma SRGAP3 pilocytic astrocytoma SRSF2 MDS, CLL SS18 synovial sarcoma SS18L1 synovial sarcoma SSX1 synovial sarcoma SSX2 synovial sarcoma SSX4 synovial sarcoma STAG2 bladder carcinoma, glioblastoma, melanoma, Ewing's sarcoma, myeloid neoplasms STAT3 T-cell large granular lymphocytic leukaemia STAT5B large granular lymphocytic leukaemia, skin basal cell, APL STAT6 solitary fibrous tumour STK11 NSCLC, pancreatic STL B-ALL SUFU medulloblastoma SUZ12 endometrial stromal tumour SYK MDS, peripheral T-cell lymphoma TAF15 extraskeletal myxoid chondrosarcoma, ALL TAL1 lymphoblastic leukaemia/biphasic TAL2 T-ALL TBL1XR1 splenic marginal zone lymphoma TCEA1 salivary adenoma TCF1 hepatic adenoma, hepatocellular TCF12 extraskeletal myxoid chondrosarcoma TCF3 pre B-ALL TCF7L2 colorectal TCL1A T-CLL TCL6 T-ALL TERT melanoma, glioblastoma, hepatocellular carcinoma, bladder, skin basal cell, skin squamous cell, mesothelioma, medulloblastoma, other tumour types TET2 MDS TFE3 papillary renal, alveolar soft part sarcoma, renal TFEB renal cell carcinoma (childhood epithelioid) TFG papillary thyroid, ALCL, NSCLC TFPT pre-B ALL TFRC NHL THRAP3 aneurysmal bone cyst TIF1 APL TLX1 T-ALL TLX3 T-ALL TMPRSS2 prostate TNFAIP3 marginal zone B-cell lymphomas, Hodgkin lymphoma, PMBL TNFRSF14 follicular lymphoma TNFRSF17 intestinal T-cell lymphoma TOP1 AML* TP53 breast, colorectal, lung, sarcoma, adrenocortical, glioma, Spitzoid tumour, multiple other tumour types TPM3 papillary thyroid, ALCL, NSCLC, Spitzoid tumour TPM4 ALCL TPR papillary thyroid, NSCLC TRA@ T-ALL TRAF7 meningioma TRB@ T-ALL TRD@ T-cell leukaemia TRIM27 papillary thyroid TRIM33 papillary thyroid TRIP11 AML TRRAP melanoma TSC1 renal cell carcinoma, bladder carcinoma TSC2 pulmonary lymphangioleiomyomatosis (LAM), renal angiomyolipoma and head and neck cancer TSHR toxic thyroid adenoma TTL ALL U2AF1 CLL, MDS UBR5 mantle cell lymphoma USP6 aneurysmal bone cyst VHL renal, haemangioma, pheochromocytoma VTI1A colorectal WAS WHSC1 MM WHSC1L1 AML WIF1 pleomorphic salivary gland adenoma WRN WT1 Wilms tumour, desmoplastic small round cell tumour WWTR1 epithelioid haemangioendothelioma XPA XPC XPO1 CLL YWHAE endometrial stromal sarcoma ZCCHC8 Spitzoid tumour ZNF145 APL ZNF198 MPN, NHL ZNF278 Ewing sarcoma ZNF331 follicular thyroid adenoma ZNF384 ALL ZNF521 ALL ZNF9 aneurysmal bone cyst ZRSR2 MDS, CLL