Description

This track provides an integrated display of DNase hypersensitivity in multiple cell types using overlapping colored graphs of signal density. with graph colors assigned to cell types based on similarity of signal. The track is based on results of experiments performed by the John Stamatoyannapoulos lab at the University of Washington from September 2007 to January 2011 as part of the ENCODE project first production phase. The signal graphs displayed here are also included in the comprehensive DnaseI HS track, which also provides peak and region calls.

Methods

Raw sequence data files were processed by the UCSC ENCODE DNase analysis pipeline described in the DNaseI HS track description. Signal graphs were normalized so the average value genome-wide is 1. Colors for the signal graphs were assigned by the UCSC BigWigCluster tool.

Credits

The processed data for this track were generated at UCSC. Credits for the primary data underlying this track are included in the DNaseI HS track description.

References

Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B et al. The accessible chromatin landscape of the human genome. Nature. 2012 Sep 6;489(7414):75-82. PMID: 22955617; PMC: PMC3721348

See also the references in the DnaseI HS track.