This directory contains alignments of the following assemblies:

  - target/reference: Dog
    (canFam4, Mar. 2020 (UU_Cfam_GSD_1.0/canFam4),
    Uppsala University)

  - query: Dog
    (canFam3, Sep. 2011 (Broad CanFam3.1/canFam3),
    Broad CanFam3.1 (GCA_000002285.2))

Files included in this directory:

  - md5sum.txt: md5sum checksums for the files in this directory

  - canFam4.canFam3.all.chain.gz: chained lastz alignments. The chain format is
    described in http://genome.ucsc.edu/goldenPath/help/chain.html .

  - canFam4.canFam3.net.gz: "net" file that describes rearrangements between
    the species and the best Dog match to any part of the
    Dog genome.  The net format is described in
    http://genome.ucsc.edu/goldenPath/help/net.html .

  - canFam4.canFam3.net.axt.gz: chained and netted alignments,
    i.e. the best chains in the Dog genome, with gaps in the best
    chains filled in by next-best chains where possible.  The axt format is
    described in http://genome.ucsc.edu/goldenPath/help/axt.html .

  - canFam4.canFam3.synNet.maf.gz - filtered net file for syntenic alignments
               only, in MAF format, see also, description of MAF format:
               http://genome.ucsc.edu/FAQ/FAQformat.html#format5

  - canFam4.canFam3.syn.net.gz - filtered net file for syntenic alignments only

  - reciprocalBest/ directory, contains reciprocal-best netted chains
    for canFam4-canFam3

The chainSwap program was used to translate canFam3-referenced chained lastz
alignments to canFam4 into canFam4-referenced chains aligned to canFam3.  See
the download directory goldenPath/canFam3/vsCanFam4/README.txt for more
information about the canFam3-referenced lastz and chaining process.

Chained alignments were processed into nets by the chainNet, netSyntenic,
and netClass programs.
Best-chain alignments in axt format were extracted by the netToAxt program.
All programs run after lastz were written by Jim Kent at UCSC.

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If you plan to download a large file or multiple files from this directory,
we recommend you use ftp rather than downloading the files via our website.
To do so, ftp to hgdownload.soe.ucsc.edu, then go to the directory
goldenPath/canFam4/vsCanFam3/. To download multiple files, use the "mget"
command:

    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all files in the current directory)

All files in this directory are freely available for public use.

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References

Chiaromonte F, Yap VB, Miller W. Scoring pairwise genomic sequence
alignments. Pac Symp Biocomput.  2002:115-26.

Kent WJ, Baertsch R, Hinrichs A, Miller W, Haussler D.
Evolution's cauldron: Duplication, deletion, and rearrangement in the
mouse and human genomes. Proc Natl Acad Sci U S A. 2003 Sep
30;100(20):11484-9.

Schwartz S, Kent WJ, Smit A, Zhang Z, Baertsch R, Hardison RC,
Haussler D, Miller W. Human-Mouse Alignments with BLASTZ. Genome
Res. 2003 Jan;13(1):103-7.

      Name                          Last modified      Size  Description
Parent Directory - canFam4.canFam3.all.chain.gz 13-May-2020 08:52 2.5G canFam4.canFam3.net.axt.gz 13-May-2020 09:19 1.3G canFam4.canFam3.net.gz 13-May-2020 11:07 16M canFam4.canFam3.syn.net.gz 13-May-2020 12:04 14M canFam4.canFam3.synNet.maf.gz 13-May-2020 12:29 1.3G md5sum.txt 26-Jun-2020 15:24 306 reciprocalBest/ 07-Jul-2020 18:32 -