This directory contains alignments of the following assemblies:

  - target/reference: Southern sea otter
    (enhLutNer1, Jun. 2019 (ASM641071v1/enhLutNer1),

  - query: Human
    (hg38, Dec. 2013 (GRCh38/hg38),
    GRCh38 Genome Reference Consortium Human Reference 38 (GCA_000001405.15))

Files included in this directory:

  - md5sum.txt: md5sum checksums for the files in this directory

  - enhLutNer1.hg38.all.chain.gz: chained lastz alignments. The chain format is
    described in .

  - "net" file that describes rearrangements between
    the species and the best Human match to any part of the
    Southern sea otter genome.  The net format is described in .

  - chained and netted alignments,
    i.e. the best chains in the Southern sea otter genome, with gaps in the best
    chains filled in by next-best chains where possible.  The axt format is
    described in .

  - enhLutNer1.hg38.synNet.maf.gz - filtered net file for syntenic alignments
               only, in MAF format, see also, description of MAF format:

  - - filtered net file for syntenic alignments only

  - reciprocalBest/ directory, contains reciprocal-best netted chains
    for enhLutNer1-hg38

The chainSwap program was used to translate hg38-referenced chained lastz
alignments to enhLutNer1 into enhLutNer1-referenced chains aligned to hg38.  See
the download directory goldenPath/hg38/vsEnhLutNer1/README.txt for more
information about the hg38-referenced lastz and chaining process.

Chained alignments were processed into nets by the chainNet, netSyntenic,
and netClass programs.
Best-chain alignments in axt format were extracted by the netToAxt program.
All programs run after lastz were written by Jim Kent at UCSC.

If you plan to download a large file or multiple files from this directory,
we recommend you use ftp rather than downloading the files via our website.
To do so, ftp to, then go to the directory
goldenPath/enhLutNer1/vsHg38/. To download multiple files, use the "mget"

    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all files in the current directory)

All files in this directory are freely available for public use.


Harris, R.S. (2007) Improved pairwise alignment of genomic DNA
Ph.D. Thesis, The Pennsylvania State University

Chiaromonte F, Yap VB, Miller W. Scoring pairwise genomic sequence
alignments. Pac Symp Biocomput.  2002:115-26.

Kent WJ, Baertsch R, Hinrichs A, Miller W, Haussler D.
Evolution's cauldron: Duplication, deletion, and rearrangement in the
mouse and human genomes. Proc Natl Acad Sci U S A. 2003 Sep

Schwartz S, Kent WJ, Smit A, Zhang Z, Baertsch R, Hardison RC,
Haussler D, Miller W. Human-Mouse Alignments with BLASTZ. Genome
Res. 2003 Jan;13(1):103-7.

      Name                           Last modified      Size  Description
Parent Directory - axtRBestNet/ 2019-12-22 14:39 - enhLutNer1.hg38.all.chain.gz 2019-12-21 22:21 461M 2019-12-21 22:47 1.1G 2019-12-21 23:11 180M enhLutNer1.hg38.rbest.chain.gz 2019-12-22 09:35 82M 2019-12-22 09:36 135M 2019-12-21 23:22 162M enhLutNer1.hg38.synNet.maf.gz 2019-12-21 23:43 1.0G hg38.enhLutNer1.rbest.chain.gz 2019-12-22 09:34 82M 2019-12-22 09:32 160M md5sum.txt 2020-05-08 16:03 306 reciprocalBest/ 2024-02-29 08:43 -