This track shows the active centromere region of each chromosome in this Human Pangenome Reference Consortium (HPRC) Release 2 assembly. The centromere is the constricted part of a chromosome where the two copies are held together and where the spindle attaches to pull them apart during cell division. Within the large satellite arrays of each chromosome, one region carries the specialized chromatin that actually recruits this machinery; that region is the "active" centromere shown here. This is a summarized companion to the more detailed centromere satellite (cenSat) track.
Each item is the active centromere interval on one sequence, drawn as a simple block. There are no sub-features.
Active centromere regions were derived from the cenSat annotation of each complete assembly, following the approach developed for the telomere-to-telomere CHM13 reference (see reference below).
The annotation files were obtained from the HPRC Release 2 data collection on the public s3://human-pangenomics bucket, indexed at the hprc_intermediate_assembly data tables. Each per-assembly BED file was converted to a UCSC bigBed file. The build scripts are in the kent source tree.
For automated analysis, the annotation is stored in a bigBed-format file (censatCentromeres.bb) that can be read with the UCSC tool bigBedToBed. The original files are available from the HPRC S3 bucket linked above.
Annotations were generated by the Human Pangenome Reference Consortium. Thanks to the HPRC production team for making these data available.
Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ et al. Complete genomic and epigenetic maps of human centromeres. Science. 2022 Apr;376(6588):eabl4178. PMID: 35357911; PMC: PMC9233505